Perils of Space Travel and Drug Stability for Mars Mission

Perils of Space Travel

Although science fiction makes space travel seem almost inevitable, current research demonstrates numerous challenges to humans residing in space for long periods of time. Along with the well-known detrimental effects on muscle mass and density, research shows that prolonged periods in space expose the human body to far more radiation than encountered here on Earth. That radiation dramatically decreases our bodies’ capacity to fight off cancer and to keep past viral exposure in check. Additionally, radiation impacts the function of our gastrointestinal system and its ability to absorb nutrients and oral medications. These results highlight Earth’s amazing capacity to host a diverse and abundant array of life.

Drug Stability for Mars Mission

Drug stability is a function of the storage environment. Shelf-lives of 2–3 years (from refrigerated to room temperature storage) are common. NASA is planning for a roundtrip mission to Mars, expected to last 2–3 years. Little is known about the stability of drugs in deep space (outside of Earth’s protective magnetosphere). Limited studies of drugs on the International Space Station raise significant questions that have identified critical parameters: microgravity, vibration, humidity, ionizing radiation, carbon dioxide levels, and repackaging. Can we ensure a safe, stable drug formulatory that will meet all of the health needs for a round-trip journey to Mars in the deep space environment?

 Links and Resources:

• Space Radiation Triggers Persistent Stress Response, Increases Senescent Signaling, and Decreases Cell Migration in Mouse Intestine
• NK Cell Function Is Impaired during Long-Duration Spaceflight
• Negative Effects of Long-Duration Spaceflight on Paraspinal Muscle Morphology